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Breast Cancer Drug Available on CDF

Bernice K. Miller by Bernice K. Miller
December 22, 2022
in Breast Canser
0

Announcements on breast cancer, lung cancer, and a single-use sterile elastic tourniquet for limb surgery feature in the latest announcements from NICE.

Summary show
Advanced Breast Cancer
Access to Psychological Therapies
The estimated cost of Velibra was £343 per person.

Advanced Breast Cancer

A potentially life-extending drug combination for some people with advanced breast cancer will be available on England’s Cancer Drugs Fund (CDF) following a National Institute for Health and Care Excellence (NICE).Breast Cancer Drug Available on CDF 1

The draft guidance recommended ribociclib (Kisqali, Novartis) with fulvestrant (Faslodex, AstraZeneca) as an option for people with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced, or metastatic breast cancer who have had previous endocrine therapy.

Clinical trial evidence suggested that compared with fulvestrant alone, the cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with fulvestrant increased the length of time before the disease progressed. However, it was unknown whether ribociclib increased the length of time people lived because final trial results were not yet available.

The committee said it recognized that ribociclib with fulvestrant had the potential to be cost-effective, and CDF listing would allow time until the end of 2020 when uncertainties around survival and cost-effectiveness were likely to be resolved.

Ribociclib is given as 3 x 200 mg tablets daily for 21 consecutive days, followed by 7 days off treatment. A pack of 63 tablets has a list price of £2950. However, the manufacturer agreed to provide the drug at a confidential discount.

Meindert Boysen, director of the NICE Centre for Health Technology Evaluation, said: “Treatments that can postpone disease progression are important because they can reduce the number of people who are exposed to the often unpleasant side-effects of chemotherapy and delay the need for its use in others.

“We are pleased, therefore, that the company has agreed on a commercial arrangement for ribociclib that will allow it to be made available to people with this type of breast cancer.”

Subject to appeal, NICE’s final guidance will be published in August.

NICE had already approved abemaciclib (Verzenios, Eli Lilly) (also a CDK4/6 inhibitor) in combination with fulvestrant for the same indication within the CDF.

Access to Psychological Therapies

NICE issued guidance on digital therapy for managing social anxiety disorder, panic disorder, and general anxiety disorder in adults under its Improving Access to Psychological Therapies (IAPT) program.

It was decided that the online program, Velibra (Gaia Group), did not meet the criteria for the evaluation in the practice phase of the NICE and NHS England IAPT assessment program.

The program, which uses the principles of cognitive-behavioral therapy, was developed as an alternative to guided or unguided self-help.

The estimated cost of Velibra was £343 per person.

IAPT services provide evidence-based psychological therapies to people with anxiety disorders and depression.

A panel of experts assesses digitally-enabled therapies for anxiety, depression, and medically unexplained symptoms, expanding these services further.

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